In 400 Nudes, Mayer selected four hundred nude selfies of women of all ages, shapes and races from the pool of millions available on the Internet. She then staged photo shoots to remake them, digitally altering the composite photos to realistically replace the original faces with her own. To explore the gaps, as well as the overlaps, between different networks of image consumption, she then re-uploaded the photos to various platforms on the net.

400 Nudes premiered at the Montreal Biennial in 2014.